Neurotransmitters, hormones, and pharmacologic agents act by binding specific receptors on the cell surface. We are interested in how a receptor initiates intracellular events such as the opening of ion channels, the activation of enzymes, or the release of intracellular calcium; and the structures, functions, and relations or receptors, G proteins, ion channels, and calcium. Our research focuses on the elucidation of signal pathways involving cardiac effector and receptor molecules. Housed in the Cardiology Department of Children's Hospital, Boston, recent studies examine the role of ion channels, G-protein linked receptors, and intracellular calcium signalling in cardiac dysfunction.

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